失张力发作怎样治疗

失张力发作如何治疗配图，仅供参考

Surgery
Patients with localized epileptic focus may benefit from surgery for complete control of IESS,especially those refractories to treatment.
Corpus callosotomy is a simple and not expensive neurosurgical procedure,affordable for our healthcare system,and an option for patients without identified lesions on MRI as a second-line treatment for those unresponsive to hormonal and antiseizure medications. In a retrospective chart review of 56 WS cases,42.9% were seizure-free; however,patients presenting psychomotor impairment before the onset of epilepsy have a worse response.
Two cases in the literature reported successful treatment with multiple subpial transactions of atypical IESS relapsed to previous therapy with ACTH and VGB,decreasing ≥ 50% of spasms.
Experts opinion
Epilepsy surgery may be recommended to selected patients,such as children with a structural lesion,in cases of cortical dysplasia or TSC. If the patient does not respond to first-line treatment and has a focal lesion,surgery should be indicated as soon as possible. Callosotomy may benefit those with intractable IESS and normal neuroimaging not responding to pharmacological therapy. Important to mention that neuroimaging,functional imaging,EEG/VEEG,and electrocorticography play a crucial role in the evaluation of patients with treatment-refractory infantile spasms who have focal cortical damage without evidence of diffuse brain damage,degenerative,or metabolic disease and who may respond to surgery. These exams provide detailed information about the location and nature of epileptiform activity in the brain,helping to guide surgical planning.","department":"